5H7O

Crystal structure of DJ-101 in complex with tubulin protein

5H7O の概要

• エントリーDOI: 10.2210/pdb5h7o/pdb
• 分子名称: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-(1H-indol-4-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine, ... (13 entities in total)
• 機能のキーワード: dj-101, colchicine site tubulin inhibitor, tubulin, taxane resistance, structural protein
• 由来する生物種: Sus scrofa (Pig); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265088.49

構造登録者

Arnst, K.,Wang, Y.,Hwang, D.-J.,Xue, Y.,Costello, T.,Hamilton, D.,Chen, Q.,Yang, J.,Park, F.,Dalton, J.T.,Miller, D.D.,Li, W. (登録日: 2016-11-20, 公開日: 2017-12-13, 最終更新日: 2022-10-12)

• 主引用文献: Arnst, K.E.,Wang, Y.,Hwang, D.J.,Xue, Y.,Costello, T.,Hamilton, D.,Chen, Q.,Yang, J.,Park, F.,Dalton, J.T.,Miller, D.D.,Li, W.; A Potent, Metabolically Stable Tubulin Inhibitor Targets the Colchicine Binding Site and Overcomes Taxane Resistance.; Cancer Res., 78:265-277, 2018; PubMed: 29180476; DOI: 10.1158/0008-5472.CAN-17-0577

実験手法

X-RAY DIFFRACTION (2.8 Å)