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5H74

Crystal structure of T2R-TTL-14b complex

5H74 の概要
エントリーDOI10.2210/pdb5h74/pdb
分子名称Tubulin alpha-1B chain, (2~{S},4~{R})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-3-[hexyl-[(2~{S},3~{S})-3-methyl-2-[[(2~{R})-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-4-methyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-(4-fluorophenyl)-2-methyl-pentanoic acid, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
機能のキーワードtubulin, complex, structural protein-inhibitor complex, structural protein/inhibitor
由来する生物種Rattus norvegicus (Rat)
詳細
細胞内の位置Cytoplasm, cytoskeleton: Q2XVP4 Q6B856
Golgi apparatus : P63043
タンパク質・核酸の鎖数6
化学式量合計266218.17
構造登録者
Wang, Y.,Yu, Y.,Chen, Q.,Yang, J. (登録日: 2016-11-17, 公開日: 2017-11-22, 最終更新日: 2024-03-20)
主引用文献Wang, Y.,Yu, Y.,Chen, Q.,Yang, J.
Structure-Activity Relationship Studies of Tubulysin Analogues: Anticancer N-Alkyltubulysins with Subpicomolar Activity and the Crystal Structure Binding to Tubulin
To Be Published,
実験手法
X-RAY DIFFRACTION (2.6 Å)
構造検証レポート
Validation report summary of 5h74
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-09-18に公開中

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