5H74

Crystal structure of T2R-TTL-14b complex

5H74 の概要

• エントリーDOI: 10.2210/pdb5h74/pdb
• 分子名称: Tubulin alpha-1B chain, (2~{S},4~{R})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-3-[hexyl-[(2~{S},3~{S})-3-methyl-2-[[(2~{R})-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]-4-methyl-pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-(4-fluorophenyl)-2-methyl-pentanoic acid, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: tubulin, complex, structural protein-inhibitor complex, structural protein/inhibitor
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton: Q2XVP4 Q6B856; Golgi apparatus : P63043
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 266218.17

構造登録者

Wang, Y.,Yu, Y.,Chen, Q.,Yang, J. (登録日: 2016-11-17, 公開日: 2017-11-22, 最終更新日: 2024-03-20)

• 主引用文献: Wang, Y.,Yu, Y.,Chen, Q.,Yang, J.; Structure-Activity Relationship Studies of Tubulysin Analogues: Anticancer N-Alkyltubulysins with Subpicomolar Activity and the Crystal Structure Binding to Tubulin; To Be Published,

実験手法

X-RAY DIFFRACTION (2.6 Å)