5H2U

Crystal structure of PTK6 Kinase Domain complexed with Dasatinib

5H2U の概要

• エントリーDOI: 10.2210/pdb5h2u/pdb
• 分子名称: Protein-tyrosine kinase 6, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: transferase, kinase, brk, ptk6, dasatinib
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q13882
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 126515.64

構造登録者

Thakur, M.K.,Birudukota, S.,Swaminathan, S.,Tyagi, R.,Gosu, R. (登録日: 2016-10-18, 公開日: 2017-01-04, 最終更新日: 2023-11-08)

• 主引用文献: Thakur, M.K.,Birudukota, S.,Swaminathan, S.,Battula, S.K.,Vadivelu, S.,Tyagi, R.,Gosu, R.; Co-crystal structures of PTK6: With Dasatinib at 2.24 angstrom , with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 angstrom resolution; Biochem. Biophys. Res. Commun., 482:1289-1295, 2017; PubMed: 27993680; DOI: 10.1016/j.bbrc.2016.12.030

実験手法

X-RAY DIFFRACTION (2.24 Å)