5H22

Hsp90 alpha N-terminal domain in complex with an inhibitor

5H22 の概要

• エントリーDOI: 10.2210/pdb5h22/pdb
• 分子名称: Hsp90aa1 protein, 4-chloranyl-7-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl]-5-(phenylmethyl)pyrrolo[2,3-d]pyrimidin-2-amine (3 entities in total)
• 機能のキーワード: hsp90, inhibitor, chaperone-inhibitor complex, chaperone/inhibitor
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24517.17

構造登録者

Kim, E.E.,Shin, S.C.,Keum, G.C. (登録日: 2016-10-13, 公開日: 2017-10-11, 最終更新日: 2023-11-08)

• 主引用文献: Lee, J.H.,Shin, S.C.,Seo, S.H.,Seo, Y.H.,Jeong, N.,Kim, C.W.,Kim, E.E.,Keum, G.; Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors.; Bioorg. Med. Chem. Lett., 27:237-241, 2017; PubMed: 27914802; DOI: 10.1016/j.bmcl.2016.11.062

実験手法

X-RAY DIFFRACTION (1.499 Å)