5H21
Trimethoxy-ring inhibitor in complex with the first bromodomain of BRD4
Summary for 5H21
Entry DOI | 10.2210/pdb5h21/pdb |
Descriptor | Bromodomain-containing protein 4, 3,4,5-trimethoxy-~{N}-(2-thiophen-2-ylethyl)benzamide (3 entities in total) |
Functional Keywords | brd4, inhibitor, peptide binding protein-inhibitor complex, peptide binding protein/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 17016.56 |
Authors | |
Primary citation | Chen, Z.,Zhang, H.,Liu, S.,Xie, Y.,Jiang, H.,Lu, W.,Xu, H.,Yue, L.,Zhang, Y.,Ding, H.,Zheng, M.,Yu, K.,Chen, K.,Jiang, H.,Luo, C. Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay. Medchemcomm, 8:1322-1331, 2017 Cited by PubMed: 30108844DOI: 10.1039/c7md00083a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.591 Å) |
Structure validation
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