5H19

EED in complex with PRC2 allosteric inhibitor EED162

5H19 の概要

• エントリーDOI: 10.2210/pdb5h19/pdb
• 関連するPDBエントリー: 5H13 5H14 5H15 5H17 5H24 5H25
• 分子名称: Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, 5-(furan-2-ylmethylamino)-9-(phenylmethyl)-8,10-dihydro-7H-[1,2,4]triazolo[3,4-a][2,7]naphthyridine-6-carbonitrile, ... (4 entities in total)
• 機能のキーワード: eed, prc2, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus: O75530 Q15910
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46362.84

構造登録者

Zhao, K.,Zhao, M.,Luo, X.,Zhang, H. (登録日: 2016-10-08, 公開日: 2017-01-25, 最終更新日: 2023-11-08)

• 主引用文献: Li, L.,Zhang, H.,Zhang, M.,Zhao, M.,Feng, L.,Luo, X.,Gao, Z.,Huang, Y.,Ardayfio, O.,Zhang, J.H.,Lin, Y.,Fan, H.,Mi, Y.,Li, G.,Liu, L.,Feng, L.,Luo, F.,Teng, L.,Qi, W.,Ottl, J.,Lingel, A.,Bussiere, D.E.,Yu, Z.,Atadja, P.,Lu, C.,Li, E.,Gu, J.,Zhao, K.; Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED; PLoS ONE, 12:e0169855-e0169855, 2017; PubMed: 28072869; DOI: 10.1371/journal.pone.0169855

実験手法

X-RAY DIFFRACTION (1.9 Å)