5H02

Crystal structure of Methanohalophilus portucalensis glycine sarcosine N-methyltransferase tetramutant (H21G, E23T, E24N, L28S)

Summary for 5H02

Entry DOI	10.2210/pdb5h02/pdb
Descriptor	Glycine sarcosine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, TRIMETHYL GLYCINE, ... (4 entities in total)
Functional Keywords	s-adenosylmethionine-dependent methyltransferases, sam, adomet-mtase, class i monomethylation, glycine, sarcosine, rate-limiting enzyme, betaine biosynthesis, betaine-mediated feedback inhibition, transferase
Biological source	Methanohalophilus portucalensis FDF-1
Total number of polymer chains	1
Total formula weight	33139.61
Authors	Lee, Y.R.,Lin, T.S.,Lai, S.J.,Liu, M.S.,Lai, M.C.,Chan, N.L. (deposition date: 2016-10-02, release date: 2016-11-23, Last modification date: 2023-11-15)
Primary citation	Lee, Y.R.,Lin, T.S.,Lai, S.J.,Liu, M.S.,Lai, M.C.,Chan, N.L. Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity. Sci Rep, 6:38071-38071, 2016 Cited by PubMed: 27934872 DOI: 10.1038/srep38071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.776 Å)

Structure validation