Structure of neutralizing antibody bound to Zika envelope protein

Summary for 5GZO

DescriptorGenome polyprotein, Antibody heavy chain, Antibody light chain (3 entities in total)
Functional Keywordszika virus, human neutralizing antibodies, envelope protein, molecular determinants, viral protein-immune system complex, viral protein/immune system
Biological sourceZika virus (ZIKV)
Cellular locationVirion membrane ; Multi-pass membrane protein  H9A910
Total number of polymer chains6
Total molecular weight182761.19
Primary citation
Wang, Q.,Yang, H.,Liu, X.,Dai, L.,Ma, T.,Qi, J.,Wong, G.,Peng, R.,Liu, S.,Li, J.,Li, S.,Song, J.,Liu, J.,He, J.,Yuan, H.,Xiong, Y.,Liao, Y.,Li, J.,Yang, J.,Tong, Z.,Griffin, B.D.,Bi, Y.,Liang, M.,Xu, X.,Qin, C.,Cheng, G.,Zhang, X.,Wang, P.,Qiu, X.,Kobinger, G.,Shi, Y.,Yan, J.,Gao, G.F.
Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
Sci Transl Med, 8:369ra179-369ra179, 2016
PubMed: 27974667 (PDB entries with the same primary citation)
DOI: 10.1126/scitranslmed.aai8336
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.278807.5%4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution