5GSQ

Crystal structure of IgG Fc with a homogeneous glycoform and Antibody-Dependent Cellular Cytotoxicity

Summary for 5GSQ

• Entry DOI: 10.2210/pdb5gsq/pdb
• Descriptor: Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: antibody fc, homogeneous n-glycan, enhanced adcc, di-sialylation, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 106418.35

Authors

Chen, C.-L.,Hsu, J.-C.,Lin, C.-W.,Wu, C.-Y.,Wong, C.-H.,Ma, C. (deposition date: 2016-08-17, release date: 2017-06-28, Last modification date: 2023-11-08)

• Primary citation: Chen, C.-L.,Hsu, J.-C.,Lin, C.-W.,Wang, C.-H.,Tsai, M.-H.,Wu, C.-Y.,Wong, C.-H.,Ma, C.; Crystal Structure of a Homogeneous IgG-Fc Glycoform with the N-Glycan Designed to Maximize the Antibody Dependent Cellular Cytotoxicity; ACS Chem. Biol., 12:1335-1345, 2017; PubMed: 28318221; DOI: 10.1021/acschembio.7b00140

Experimental method

X-RAY DIFFRACTION (1.85 Å)