5GSQ

Crystal structure of IgG Fc with a homogeneous glycoform and Antibody-Dependent Cellular Cytotoxicity

5GSQ の概要

• エントリーDOI: 10.2210/pdb5gsq/pdb
• 分子名称: Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: antibody fc, homogeneous n-glycan, enhanced adcc, di-sialylation, immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 106418.35

構造登録者

Chen, C.-L.,Hsu, J.-C.,Lin, C.-W.,Wu, C.-Y.,Wong, C.-H.,Ma, C. (登録日: 2016-08-17, 公開日: 2017-06-28, 最終更新日: 2023-11-08)

• 主引用文献: Chen, C.-L.,Hsu, J.-C.,Lin, C.-W.,Wang, C.-H.,Tsai, M.-H.,Wu, C.-Y.,Wong, C.-H.,Ma, C.; Crystal Structure of a Homogeneous IgG-Fc Glycoform with the N-Glycan Designed to Maximize the Antibody Dependent Cellular Cytotoxicity; ACS Chem. Biol., 12:1335-1345, 2017; PubMed: 28318221; DOI: 10.1021/acschembio.7b00140

実験手法

X-RAY DIFFRACTION (1.85 Å)