5GN1

Crystal structure of the C-terminal part of Fun30 ATPase domain

5GN1 の概要

• エントリーDOI: 10.2210/pdb5gn1/pdb
• 分子名称: ATP-dependent helicase FUN30 (2 entities in total)
• 機能のキーワード: helicase, reca, remodeler, hydrolase
• 由来する生物種: Saccharomyces cerevisiae S288c
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 169627.91

構造登録者

Jiang, T.,Liu, L. (登録日: 2016-07-18, 公開日: 2017-01-11, 最終更新日: 2023-11-08)

主引用文献

Liu, L.,Jiang, T.
Crystal structure of the ATPase-C domain of the chromatin remodeller Fun30 from Saccharomyces cerevisiae.
Acta Crystallogr.,Sect.F, 73:9-15, 2017

PubMed Abstract: Fun30 (Function unknown now 30) is a chromatin remodeller belonging to the Snf2 family. It has previously been reported to be a regulator of several cellular activities, including DNA repair, gene silencing and maintenance of chromatin structure. Here, the crystal structure of the Fun30 ATPase-C domain (the C-lobe of the ATPase domain) is reported at 1.95 Å resolution. Although the structure displays overall similarities to those of other Snf2 family members, a new structural module was found to be specific to the Fun30 subfamily. Fun30 ATPase-C was shown be monomeric in solution and showed no detectable affinity for dsDNA.

PubMed: 28045388
DOI: 10.1107/S2053230X16019269

実験手法

X-RAY DIFFRACTION (1.95 Å)