5GMP
Crystal structure of EGFR 696-1022 T790M in complex with XTF-262
Summary for 5GMP
Entry DOI | 10.2210/pdb5gmp/pdb |
Descriptor | Epidermal growth factor receptor, N-[3-[2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-7-oxidanylidene-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide (3 entities in total) |
Functional Keywords | egfr, t790m, xtf-262, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 1 |
Total formula weight | 38176.20 |
Authors | |
Primary citation | Yu, L.,Huang, M.,Xu, T.,Tong, L.,Yan, X.E.,Zhang, Z.,Xu, Y.,Yun, C.,Xie, H.,Ding, K.,Lu, X. A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties. Eur J Med Chem, 126:1107-1117, 2017 Cited by PubMed: 28033579DOI: 10.1016/j.ejmech.2016.12.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.797 Å) |
Structure validation
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