5GMP

Crystal structure of EGFR 696-1022 T790M in complex with XTF-262

5GMP の概要

• エントリーDOI: 10.2210/pdb5gmp/pdb
• 分子名称: Epidermal growth factor receptor, N-[3-[2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-7-oxidanylidene-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide (3 entities in total)
• 機能のキーワード: egfr, t790m, xtf-262, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38176.20

構造登録者

Yan, X.E.,Yun, C.H. (登録日: 2016-07-14, 公開日: 2017-06-28, 最終更新日: 2023-11-08)

• 主引用文献: Yu, L.,Huang, M.,Xu, T.,Tong, L.,Yan, X.E.,Zhang, Z.,Xu, Y.,Yun, C.,Xie, H.,Ding, K.,Lu, X.; A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties.; Eur J Med Chem, 126:1107-1117, 2017; PubMed: 28033579; DOI: 10.1016/j.ejmech.2016.12.006

実験手法

X-RAY DIFFRACTION (2.797 Å)