5GKR

Crystal structure of SLE patient-derived anti-DNA antibody in complex with oligonucleotide

Summary for 5GKR

• Entry DOI: 10.2210/pdb5gkr/pdb
• Related: 5GKS
• Descriptor: IgG2, Fab (heavy chain), lambda, Fab (light chain), DNA (5'-D(P*TP*TP*TP*T)-3'), ... (4 entities in total)
• Functional Keywords: antibody, lupus, dna, fab, immune system-dna complex, immune system/dna
• Biological source: Homo sapiens; More
• Total number of polymer chains: 5
• Total formula weight: 93862.87

Authors

Arimori, T.,Sakakibara, S.,Kikutani, H.,Takagi, J. (deposition date: 2016-07-05, release date: 2017-07-05, Last modification date: 2023-11-08)

• Primary citation: Sakakibara, S.,Arimori, T.,Yamashita, K.,Jinzai, H.,Motooka, D.,Nakamura, S.,Li, S.,Takeda, K.,Katayama, J.,El Hussien, M.A.,Narazaki, M.,Tanaka, T.,Standley, D.M.,Takagi, J.,Kikutani, H.; Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus; Sci Rep, 7:16428-16428, 2017; PubMed: 29180749; DOI: 10.1038/s41598-017-16681-y

Experimental method

X-RAY DIFFRACTION (2.1 Å)