5GIM

Crystal structure of thrombin-avathrin complex

5GIM の概要

• エントリーDOI: 10.2210/pdb5gim/pdb
• 分子名称: Thrombin light chain, thrombin heavy chain, N-terminal peptide from Putative uncharacterized protein avahiru, ... (5 entities in total)
• 機能のキーワード: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 37037.17

構造登録者

Kini, R.M.,Koh, C.Y.,Iyer, J.K.,Swaminathan, K. (登録日: 2016-06-24, 公開日: 2017-05-03, 最終更新日: 2023-11-08)

• 主引用文献: Iyer, J.K.,Koh, C.Y.,Kazimirova, M.,Roller, L.,Jobichen, C.,Swaminathan, K.,Mizuguchi, J.,Iwanaga, S.,Nuttall, P.A.,Chan, M.Y.,Kini, R.M.; Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum.; FASEB J., 31:2981-2995, 2017; PubMed: 28363953; DOI: 10.1096/fj.201601216R

実験手法

X-RAY DIFFRACTION (2.09 Å)