5GHZ

Crystal structure of beta-lactamase PenP mutant-E166H in complex with cephaloridine as "pre-deacylation" intermediate

Summary for 5GHZ

• Entry DOI: 10.2210/pdb5ghz/pdb
• Related: 5GHX 5GHY
• Descriptor: Beta-lactamase, 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID (3 entities in total)
• Functional Keywords: hydrolase
• Biological source: Bacillus licheniformis
• Cellular location: Cell membrane ; Lipid-anchor : P00808
• Total number of polymer chains: 2
• Total formula weight: 60354.50

Authors

Pan, X.,Zhao, Y. (deposition date: 2016-06-21, release date: 2017-01-25, Last modification date: 2017-03-22)

• Primary citation: Pan, X.,He, Y.,Lei, J.,Huang, X.,Zhao, Y.; Crystallographic Snapshots of Class A beta-Lactamase Catalysis Reveal Structural Changes That Facilitate beta-Lactam Hydrolysis; J. Biol. Chem., 292:4022-4033, 2017; PubMed: 28100776; DOI: 10.1074/jbc.M116.764340

Experimental method

X-RAY DIFFRACTION (1.93 Å)