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5GHN

Crystal structure of human MTH1(G2K/D120N mutant) in complex with 2-oxo-dATP

Summary for 5GHN
Entry DOI10.2210/pdb5ghn/pdb
Related5GHI 5GHJ 5GHM 5GHO 5GHP 5GHQ
Descriptor7,8-dihydro-8-oxoguanine triphosphatase, [[(2R,3S,5R)-5-(6-azanyl-2-oxidanylidene-1H-purin-9-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate, SODIUM ION, ... (4 entities in total)
Functional Keywordsalpha-beta-alpha sandwich, hydrolase, dna damage, dna repair, dna replication
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight37168.54
Authors
Nakamura, T.,Waz, S.,Hirata, K.,Nakabeppu, Y.,Yamagata, Y. (deposition date: 2016-06-20, release date: 2017-01-04, Last modification date: 2024-03-20)
Primary citationWaz, S.,Nakamura, T.,Hirata, K.,Koga-Ogawa, Y.,Chirifu, M.,Arimori, T.,Tamada, T.,Ikemizu, S.,Nakabeppu, Y.,Yamagata, Y.
Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
J. Biol. Chem., 292:2785-2794, 2017
Cited by
PubMed: 28035004
DOI: 10.1074/jbc.M116.749713
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.391 Å)
Structure validation

217705

건을2024-03-27부터공개중

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