5GGZ

Crystal structure of novel inhibitor bound with Hsp90

Summary for 5GGZ

Entry DOI	10.2210/pdb5ggz/pdb
Descriptor	Heat shock protein HSP 90-alpha, [2,4-bis(oxidanyl)-5-propan-2-yl-phenyl]-(2-ethoxy-7,8-dihydro-5~{H}-pyrido[4,3-d]pyrimidin-6-yl)methanone (3 entities in total)
Functional Keywords	hsp90, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P07900
Total number of polymer chains	4
Total formula weight	95628.62
Authors	Chen, T.T.,Li, J.,Xu, Y.C. (deposition date: 2016-06-16, release date: 2017-03-08, Last modification date: 2024-03-20)
Primary citation	Jiang, F.,Wang, H.J.,Jin, Y.H.,Zhang, Q.,Wang, Z.H.,Jia, J.M.,Liu, F.,Wang, L.,Bao, Q.C.,Li, D.D.,You, Q.D.,Xu, X.L. Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90 J. Med. Chem., 59:10498-10519, 2016 Cited by PubMed: 27933959 DOI: 10.1021/acs.jmedchem.6b00912 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.015 Å)

Structure validation