5GGO

Crystal structure of N-terminal domain of human protein O-mannose beta-1,2-N-acetylglucosaminyltransferase in complex with GalNac-beta1,3-GlcNAc-beta-pNP

Summary for 5GGO

Related5GGF 5GGG 5GGI 5GGJ 5GGK 5GGL 5GGN 5GGP
DescriptorProtein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1, N-[(2S,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(4-nitrophenoxy)oxan-3-yl]ethanamide, N-ACETYL-D-GALACTOSAMINE, ... (5 entities in total)
Functional Keywordsglycosyltransferease, o-mannosylation, alpha-dystroglycan, sugar binding protein
Biological sourceHomo sapiens (Human)
Cellular locationGolgi apparatus membrane ; Single-pass type II membrane protein  Q8WZA1
Total number of polymer chains2
Total molecular weight36435.13
Authors
Kuwabara, N.,Senda, T.,Kato, R. (deposition date: 2016-06-16, release date: 2016-08-10, Last modification date: 2016-08-31)
Primary citation
Kuwabara, N.,Manya, H.,Yamada, T.,Tateno, H.,Kanagawa, M.,Kobayashi, K.,Akasaka-Manya, K.,Hirose, Y.,Mizuno, M.,Ikeguchi, M.,Toda, T.,Hirabayashi, J.,Senda, T.,Endo, T.,Kato, R.
Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of alpha-dystroglycan
Proc.Natl.Acad.Sci.USA, 113:9280-9285, 2016
PubMed: 27493216 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1525545113
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.502 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.207400.8%0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution