5G4S
BROMODOMAIN OF HUMAN BRPF1 WITH N-1,3-dimethyl-6-2R-2- methylpiperazin-1-yl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl-N- ethyl-2-methoxybenzamide
Summary for 5G4S
Entry DOI | 10.2210/pdb5g4s/pdb |
Related | 5G4R |
Descriptor | PEREGRIN, N-[1,3-dimethyl-6-[(2R)-2-methylpiperazin-1-yl]-2-oxidanylidene-benzimidazol-5-yl]-N-ethyl-2-methoxy-benzamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | transcription |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus : P55201 |
Total number of polymer chains | 1 |
Total formula weight | 14426.50 |
Authors | Chung, C. (deposition date: 2016-05-16, release date: 2016-07-06, Last modification date: 2024-05-08) |
Primary citation | Bamborough, P.,Barnett, H.A.,Becher, I.,Bird, M.J.,Chung, C.,Craggs, P.D.,Demont, E.H.,Diallo, H.,Fallon, D.J.,Gordon, L.J.,Grandi, P.,Hobbs, C.I.,Hooper-Greenhill, E.,Jones, E.J.,Law, R.P.,Le Gall, A.,Lugo, D.,Michon, A.,Mitchell, D.J.,Prinjha, R.K.,Sheppard, R.J.,Watson, A.J.B.,Watson, R.J. Gsk6853, a Chemical Probe for Inhibition of the Brpf1 Bromodomain. Acs Med.Chem.Lett., 7:552-, 2016 Cited by PubMed: 27326325DOI: 10.1021/ACSMEDCHEMLETT.6B00092 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report