5G1N

Aspartate transcarbamoylase domain of human CAD bound to PALA

Summary for 5G1N

Entry DOI	10.2210/pdb5g1n/pdb
Related	5G1O 5G1P
Descriptor	CAD PROTEIN, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	transferase, de novo pyrimidine synthesis, transcarbamoylase, transcarbamylase, cad, carbamoyl phosphate synthetase, dihydroorotase, cooperativity
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : P27708
Total number of polymer chains	6
Total formula weight	211123.38
Authors	Ruiz-Ramos, A.,Grande-Garcia, A.,Moreno-Morcillo, M.D.,Ramon-Maiques, S. (deposition date: 2016-03-29, release date: 2016-06-22, Last modification date: 2024-01-10)
Primary citation	Ruiz-Ramos, A.,Velazquez-Campoy, A.,Grande-Garcia, A.,Moreno-Morcillo, M.,Ramon-Maiques, S. Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-Tumoral Drug Pala. Structure, 24:1081-, 2016 Cited by PubMed: 27265852 DOI: 10.1016/J.STR.2016.05.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation