5G0O

Structure of rat neuronal nitric oxide synthase D597N mutant heme domain in complex with 4-METHYL-6-(2-(5-(4-METHYLPIPERAZIN-1-YL) PYRIDIN-3-YL)ETHYL)PYRIDIN-2-AMINE

Summary for 5G0O

Related5G0N 5G0P
DescriptorNITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsoxidoreductase, nitric oxide synthase, inhibitor complex
Biological sourceRATTUS NORVEGICUS (NORWAY RAT)
Cellular locationCell membrane, sarcolemma ; Peripheral membrane protein  P29476
Total number of polymer chains2
Total molecular weight100144.9
Authors
Li, H.,Poulos, T.L. (deposition date: 2016-03-21, release date: 2016-06-15, Last modification date: 2016-07-20)
Primary citation
Li, H.,Wang, H.,Kang, S.,Silverman, R.B.,Poulos, T.L.
Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase.
Biochemistry, 55:3702-, 2016
PubMed: 27250740 (PDB entries with the same primary citation)
DOI: 10.1021/ACS.BIOCHEM.6B00261
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23140.2%3.2%3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution