5G0N

Structure of rat neuronal nitric oxide synthase D597N mutant heme domain in complex with N1-(5-(2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL) PYRIDIN-3-YL)-N1,N2-DIMETHYLETHANE-1,2-DIAMINE

5G0N の概要

• エントリーDOI: 10.2210/pdb5g0n/pdb
• 関連するPDBエントリー: 5G0O 5G0P
• 分子名称: NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, nitric oxide synthase, inhibitor complex
• 由来する生物種: RATTUS NORVEGICUS (NORWAY RAT)
• 細胞内の位置: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100120.88

構造登録者

Li, H.,Poulos, T.L. (登録日: 2016-03-21, 公開日: 2016-06-15, 最終更新日: 2016-07-27)

• 主引用文献: Li, H.,Wang, H.,Kang, S.,Silverman, R.B.,Poulos, T.L.; Electrostatic Control of Isoform Selective Inhibitor Binding in Nitric Oxide Synthase.; Biochemistry, 55:3702-, 2016; PubMed: 27250740; DOI: 10.1021/ACS.BIOCHEM.6B00261

実験手法

X-RAY DIFFRACTION (1.936 Å)