5FZW

High resolution solution NMR structure of the spider venom peptide U3- scytotoxin-Sth1h

Summary for 5FZW

• Entry DOI: 10.2210/pdb5fzw/pdb
• Related: 5FZV 5FZX
• NMR Information: BMRB: 26003
• Descriptor: Venom peptide U3-SYTX-Sth1h (1 entity in total)
• Functional Keywords: toxin, spider venom peptide, ick
• Biological source: Scytodes thoracica
• Total number of polymer chains: 1
• Total formula weight: 3622.33

Authors

Loening, N.M. (deposition date: 2016-03-15, release date: 2016-06-08, Last modification date: 2023-06-14)

Primary citation

Ariki, N.K.,Munoz, L.E.,Armitage, E.L.,Goodstein, F.R.,George, K.G.,Smith, V.L.,Vetter, I.,Herzig, V.,King, G.F.,Loening, N.M.
Characterization of Three Venom Peptides from the Spitting Spider Scytodes Thoracica.
Plos One, 11:56291-, 2016

PubMed Abstract: We present the solution-state NMR structures and preliminary functional characterizations of three venom peptides identified from the spitting spider Scytodes thoracica. Despite little sequence identity to other venom peptides, structural characterization reveals that these peptides contain an inhibitor cystine knot motif common to many venom peptides. These are the first structures for any peptide or protein from spiders of the Scytodidae family. Many venom peptides target neuronal ion channels or receptors. However, we have not been able to determine the target of these Scytodes peptides so we can only state with certainty the channels and receptors that they do not target.

PubMed: 27227898
DOI: 10.1371/JOURNAL.PONE.0156291

Experimental method

SOLUTION NMR