5FV2
Crystal structure of hVEGF in complex with VH domain antibody
Summary for 5FV2
Entry DOI | 10.2210/pdb5fv2/pdb |
Related | 5FV1 |
Descriptor | VH DOMAIN ANTIBODY, VASCULAR ENDOTHELIAL GROWTH FACTOR (2 entities in total) |
Functional Keywords | hormone, growth factor receptor, vegf, domain antibody, vascular endothelial growth factor |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 6 |
Total formula weight | 78881.45 |
Authors | Chung, C.,Batuwangala, T. (deposition date: 2016-02-02, release date: 2016-02-17, Last modification date: 2019-05-15) |
Primary citation | Walker, A.,Chung, C.,Neu, M.,Burman, M.,Batuwangala, T.,Jones, G.,Tang, C.,Steward, M.,Mullin, M.,Tournier, N.,Lewis, A.,Korczynska, J.,Chung, V.,Catchpole, I. Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept. J.Biol.Chem., 291:5500-, 2016 Cited by PubMed: 26728464DOI: 10.1074/JBC.M115.691162 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.45 Å) |
Structure validation
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