5FUM

Mus musculus acetylcholinesterase in complex with AL200

5FUM の概要

• エントリーDOI: 10.2210/pdb5fum/pdb
• 分子名称: ACETYLCHOLINESTERASE, 2-(biphenyl-4-yloxy)-1-[4-(4-ethylpiperazin-1-yl)piperidin-1-yl]ethanone, 2-(2-METHOXYETHOXY)ETHANOL, ... (5 entities in total)
• 機能のキーワード: hydrolase, acetylcholinesterase, vector control, insecticide, selective, malaria, dengue
• 由来する生物種: MUS MUSCULUS (HOUSE MOUSE)
• 細胞内の位置: Cell junction, synapse. Isoform H: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side: P21836
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 122238.24

構造登録者

Knutsson, S.,Engdahl, C.,Ekstrom, F.,Linusson, A. (登録日: 2016-01-28, 公開日: 2016-09-21, 最終更新日: 2018-01-17)

• 主引用文献: Engdahl, C.,Knutsson, S.,Ekstrom, F.J.,Linusson, A.; Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes.; J.Med.Chem., 17:2724-, 2016; PubMed: 27598521; DOI: 10.1021/ACS.JMEDCHEM.6B00967

実験手法

X-RAY DIFFRACTION (2.5 Å)