5FTQ

Crystal structure of the ALK kinase domain in complex with Cmpd 17

5FTQ の概要

• エントリーDOI: 10.2210/pdb5ftq/pdb
• 関連するPDBエントリー: 5FTO
• 分子名称: ALK TYROSINE KINASE RECEPTOR, N-[5-(3,5-DIFLUOROBENZYL)-1H-INDAZOL-3-YL]-2-[(4-HYDROXYCYCLOHEXYL)AMINO]-4-(4-METHYLPIPERAZIN-1-YL) BENZAMIDE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: transferase, kinase inhibitors, cancer, drug discovery, alk, trk, ros1, anaplastic large cell lymphoma (alcl), non small cell large cancer (nsclc), neuroblastoma, colorectal cancer (crc)
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : Q9UM73
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36001.37

構造登録者

Bossi, R.,Canevari, G.,Fasolini, M.,Menichincheri, M.,Ardini, E.,Magnaghi, P.,Avanzi, N.,Banfi, P.,Buffa, L.,Ceriani, L.,Colombo, M.,Corti, L.,Donati, D.,Felder, E.,Fiorelli, C.,Fiorentini, F.,Galvani, A.,Isacchi, A.,Lombardi Borgia, A.,Marchionni, C.,Nesi, M.,Orrenius, C.,Panzeri, A.,Perrone, E.,Pesenti, E.,Rusconi, L.,Saccardo, M.B.,Vanotti, E.,Orsini, P. (登録日: 2016-01-14, 公開日: 2016-04-06, 最終更新日: 2024-01-10)

• 主引用文献: Menichincheri, M.,Ardini, E.,Magnaghi, P.,Avanzi, N.,Banfi, P.,Bossi, R.T.,Buffa, L.,Canevari, G.,Ceriani, L.,Colombo, M.,Corti, L.,Donati, D.,Fasolini, M.,Felder, E.R.,Fiorelli, C.,Fiorentini, F.,Galvani, A.,Isacchi, A.,Borgia, A.L.,Marchionni, C.,Nesi, M.,Orrenius, C.,Panzeri, A.,Pesenti, E.,Rusconi, L.,Saccardo, B.M.,Vanotti, E.,Perrone, E.,Orsini, P.; Discovery of Entrectinib: A New 3-Aminoindazole as a Potent Anaplastic Lymphoma Kinase (Alk), C-Ros Oncogene 1 Kinase (Ros1), and Pan-Tropomyosin Receptor Kinases (Pan-Trks) Inhibitor.; J.Med.Chem., 59:3392-, 2016; PubMed: 27003761; DOI: 10.1021/ACS.JMEDCHEM.6B00064

実験手法

X-RAY DIFFRACTION (1.7 Å)