5FQV

Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 5.

5FQV の概要

• エントリーDOI: 10.2210/pdb5fqv/pdb
• 関連するPDBエントリー: 5FQP 5FQR 5FQS 5FQT
• 分子名称: ESTROGEN RECEPTOR ALPHA, (E)-3-[4-(6-hydroxy-2-isobutyl-7-methyl-3,4-dihydro-1H-isoquinolin-1-yl)phenyl]prop-2-enoic acid (3 entities in total)
• 機能のキーワード: signaling protein, breast cancer, estrogen receptor downregulator, fulvestrant, thiq, nuclear hormone receptor
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28623.58

構造登録者

Scott, J.S.,bailey, A.,Davies, R.D.M.,Degorce, S.L.,MacFaul, P.A.,Gingell, H.,Moss, T.,Norman, R.A.,Pink, J.H.,Rabow, A.A.,Roberts, B.,Smith, P.D. (登録日: 2015-12-14, 公開日: 2016-02-10, 最終更新日: 2024-05-08)

• 主引用文献: Scott, J.S.,Bailey, A.,Davies, R.D.M.,Degorce, S.L.,Macfaul, P.A.,Gingell, H.,Moss, T.,Norman, R.A.,Pink, J.H.,Rabow, A.A.,Roberts, B.,Smith, P.D.; Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.; Acs Med.Chem.Lett., 7:94-, 2016; PubMed: 26819673; DOI: 10.1021/ACSMEDCHEMLETT.5B00413

実験手法

X-RAY DIFFRACTION (1.74 Å)