5FPU

Crystal structure of human JARID1B in complex with GSKJ1

Summary for 5FPU

Entry DOI	10.2210/pdb5fpu/pdb
Related	5FPL 5FPV
Descriptor	LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, ... (8 entities in total)
Functional Keywords	transcription, lysine-specific demethylase 5b
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : Q9UGL1
Total number of polymer chains	1
Total formula weight	56826.31
Authors	Srikannathasan, V.,Nowak, R.,Johansson, C.,Gileadi, C.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Oppermann, U. (deposition date: 2015-12-03, release date: 2016-01-13, Last modification date: 2024-01-10)
Primary citation	Johansson, C.,Velupillai, S.,Tumber, A.,Szykowska, A.,Hookway, E.S.,Nowak, R.P.,Strain-Damerell, C.,Gileadi, C.,Philpott, M.,Burgess-Brown, N.,Wu, N.,Kopec, J.,Nuzzi, A.,Steuber, H.,Egner, U.,Badock, V.,Munro, S.,Lathangue, N.B.,Westaway, S.,Brown, J.,Athanasou, N.,Prinjha, R.,Brennan, P.E.,Oppermann, U. Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12:539-, 2016 Cited by PubMed: 27214403 DOI: 10.1038/NCHEMBIO.2087 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.24 Å)

Structure validation