5FP5

Structure of cyclin-dependent kinase 2 with small-molecule ligand 4- fluorobenzoic acid (AT222) in an alternate binding site.

Summary for 5FP5

• Entry DOI: 10.2210/pdb5fp5/pdb
• Related: 5FP6
• Descriptor: CYCLIN-DEPENDENT KINASE 2, 4-fluorobenzoic acid, ACETYL GROUP, ... (4 entities in total)
• Functional Keywords: transferase, kinase, mitosis, cell cycle, fragment screening, alternate binding site.
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 34300.76

Authors

Jhoti, H.,Ludlow, R.F.,O'Reilly, M.,Saini, H.K.,Tickle, I.J.,Verdonk, M. (deposition date: 2015-11-27, release date: 2015-12-09, Last modification date: 2024-01-10)

• Primary citation: Ludlow, R.F.,Verdonk, M.L.,Saini, H.K.,Tickle, I.J.,Jhoti, H.; Detection of Secondary Binding Sites in Proteins Using Fragment Screening.; Proc.Natl.Acad.Sci.USA, 112:15910-15915, 2015; PubMed: 26655740; DOI: 10.1073/PNAS.1518946112

Experimental method

X-RAY DIFFRACTION (2.16 Å)