5FOA

Crystal Structure of Human Complement C3b in complex with DAF (CCP2-4)

5FOA の概要

• エントリーDOI: 10.2210/pdb5foa/pdb
• 関連するPDBエントリー: 5FO7 5FO8 5FO9 5FOB
• 分子名称: COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA CHAIN, DECAY ACCELERATING FACTOR, CD55 (3 entities in total)
• 機能のキーワード: lipid binding, complement system, immune system, plasma protein, regulators of complement activity, decay-accelerating activity
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Secreted: P01024 P08174; Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor. Isoform 3: Secreted . Isoform 4: Secreted . Isoform 5: Secreted . Isoform 6: Cell membrane ; Lipid-anchor, GPI-anchor . Isoform 7: Cell membrane ; Lipid-anchor, GPI-anchor : P01024
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 393516.70

構造登録者

Forneris, F.,Wu, J.,Xue, X.,Gros, P. (登録日: 2015-11-18, 公開日: 2016-04-06, 最終更新日: 2024-01-10)

• 主引用文献: Forneris, F.,Wu, J.,Xue, X.,Ricklin, D.,Lin, Z.,Sfyroera, G.,Tzekou, A.,Volokhina, E.,Granneman, J.C.,Hauhart, R.,Bertram, P.,Liszewski, M.K.,Atkinson, J.P.,Lambris, J.D.,Gros, P.; Regulators of Complement Activity Mediate Inhibitory Mechanisms Through a Common C3B-Binding Mode.; Embo J., 35:1133-, 2016; PubMed: 27013439; DOI: 10.15252/EMBJ.201593673

実験手法

X-RAY DIFFRACTION (4.188 Å)