5FN2

Cryo-EM structure of gamma secretase in complex with a drug DAPT

Summary for 5FN2

• Entry DOI: 10.2210/pdb5fn2/pdb
• Related: 5FN3 5FN4 5FN5
• EMDB information: 3237
• Descriptor: Nicastrin, Presenilin-1, Gamma-secretase subunit APH-1A, ... (4 entities in total)
• Functional Keywords: hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 172191.01

Authors

Bai, X.C.,Rajendra, E.,Yang, G.H.,Shi, Y.G.,Scheres, S.H.W. (deposition date: 2015-11-10, release date: 2015-12-16, Last modification date: 2019-09-04)

• Primary citation: Bai, X.C.,Rajendra, E.,Yang, G.,Shi, Y.,Scheres, S.H.; Sampling the conformational space of the catalytic subunit of human gamma-secretase.; Elife, 4:-, 2015; PubMed: 26623517; DOI: 10.7554/eLife.11182

Experimental method

ELECTRON MICROSCOPY (4.2 Å)