5FMA

human Notch 1, EGF 4-7

5FMA の概要

• エントリーDOI: 10.2210/pdb5fma/pdb
• 関連するPDBエントリー: 5FM9
• 分子名称: NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, CALCIUM ION, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: transcription, transmembrane, developmental, protein, notch signaling pathway, differentiation, phosphorylation, egf- like domain, regulation, receptor, activator, ank repeat, signalling, glycoprotein, extracellular, egf, notch, jagged, membrane
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein . Notch 1 intracellular domain: Nucleus : P46531
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33161.63

構造登録者

Weisshuhn, P.C.,Sheppard, D.,Taylor, P.,Whiteman, P.,Lea, S.M.,Handford, P.A.,Redfield, C. (登録日: 2015-11-02, 公開日: 2016-04-13, 最終更新日: 2024-01-10)

• 主引用文献: Weisshuhn, P.C.,Sheppard, D.,Taylor, P.,Whiteman, P.,Lea, S.M.,Handford, P.A.,Redfield, C.; Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.; Structure, 24:555-, 2016; PubMed: 26996961; DOI: 10.1016/J.STR.2016.02.010

実験手法

X-RAY DIFFRACTION (2.46 Å)