5FM3

Crystal structure of hyper-phosphorylated RET kinase domain with (proximal) juxtamembrane segment

Summary for 5FM3

• Entry DOI: 10.2210/pdb5fm3/pdb
• Related: 5FM2
• Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE (3 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 41002.75

Authors

Plaza-Menacho, I.,Barnouin, K.,Barry, R.,Borg, A.,Orme, M.,Mouilleron, S.,Martinez-Torres, R.J.,Meier, P.,McDonald, N.Q. (deposition date: 2015-10-30, release date: 2016-12-28, Last modification date: 2019-04-24)

• Primary citation: Plaza-Menacho, I.,Barnouin, K.,Barry, R.,Borg, A.,Orme, M.,Chauhan, R.,Mouilleron, S.,Martinez-Torres, R.J.,Meier, P.,McDonald, N.Q.; RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.; Cell Rep, 17:3319-3332, 2016; PubMed: 28009299; DOI: 10.1016/j.celrep.2016.11.061

Experimental method

X-RAY DIFFRACTION (2.95 Å)