5FM2
Crystal structure of hyper-phosphorylated RET kinase domain with (proximal) juxtamembrane segment
Summary for 5FM2
Entry DOI | 10.2210/pdb5fm2/pdb |
Related | 5FM3 |
Descriptor | PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE (3 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 41002.75 |
Authors | Plaza-Menacho, I.,Barnouin, K.,Barry, R.,Borg, A.,Orme, M.,Mouilleron, S.,Martinez-Torres, R.J.,Meier, P.,McDonald, N.Q. (deposition date: 2015-10-30, release date: 2016-12-28, Last modification date: 2019-04-24) |
Primary citation | Plaza-Menacho, I.,Barnouin, K.,Barry, R.,Borg, A.,Orme, M.,Chauhan, R.,Mouilleron, S.,Martinez-Torres, R.J.,Meier, P.,McDonald, N.Q. RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements. Cell Rep, 17:3319-3332, 2016 Cited by PubMed: 28009299DOI: 10.1016/j.celrep.2016.11.061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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