5FLX

Mammalian 40S HCV-IRES complex

Summary for 5FLX

EMDB information3221
Descriptor18S RRNA, 40S RIBOSOMAL PROTEIN SA, 40S RIBOSOMAL PROTEIN S3A, ... (37 entities in total)
Functional Keywordsribosome, translation initiation, hepatitis c virus internal ribosome entry site
Biological sourceHEPATITIS C VIRUS (HCV)
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Cellular locationCell membrane P08865
Cytoplasm  P61247 P23396 P62241 P46781 P46783 P25398 P62269 P60866
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome  P62081
Nucleus  P39019
Ubiquitin: Cytoplasm  P62979
Cell membrane ; Peripheral membrane protein P63244
Total number of polymer chains35
Total molecular weight1385962.24
Authors
Primary citation
Yamamoto, H.,Collier, M.,Loerke, J.,Ismer, J.,Schmidt, A.,Hilal, T.,Sprink, T.,Yamamoto, K.,Mielke, T.,Burger, J.,Shaikh, T.R.,Dabrowski, M.,Hildebrand, P.W.,Scheerer, P.,Spahn, C.M.
Molecular Architecture of the Ribosome-Bound Hepatitis C Virus Internal Ribosomal Entry Site RNA.
Embo J., 34:3042-, 2015
PubMed: 26604301 (PDB entries with the same primary citation)
DOI: 10.15252/EMBJ.201592469
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY (3.9 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone160.6%0.2%0.54MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 5flx
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Molmil generated image of 5flx
rotated about x axis by 90°
Molmil generated image of 5flx
rotated about y axis by 90°