5FKY
Structure of a hydrolase bound with an inhibitor
Summary for 5FKY
Entry DOI | 10.2210/pdb5fky/pdb |
Related | 5FL0 5FL1 |
Descriptor | O-GLCNACASE BT_4395, GLYCEROL, (3aR,5R,6S,7R,7aR)-2-amino-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol, ... (4 entities in total) |
Functional Keywords | hydrolase |
Biological source | BACTEROIDES THETAIOTAOMICRON |
Total number of polymer chains | 2 |
Total formula weight | 165164.80 |
Authors | Cekic, N.,Heinonen, J.E.,Stubbs, K.A.,Roth, C.,McEachern, E.J.,Davies, G.J.,Vocadlo, D.J. (deposition date: 2015-10-20, release date: 2016-01-27, Last modification date: 2018-08-29) |
Primary citation | Cekic, N.,Heinonen, J.E.,Stubbs, K.A.,Roth, C.,He, Y.,Bennet, A.J.,McEachern, E.J.,Davies, G.J.,Vocadlo, D.J. Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by humanO-GlcNAcase. Chem Sci, 7:3742-3750, 2016 Cited by PubMed: 29997861DOI: 10.1039/c6sc00370b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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