5FKJ

Crystal structure of mouse acetylcholinesterase in complex with C-547, an alkyl ammonium derivative of 6-methyl uracil

5FKJ の概要

• エントリーDOI: 10.2210/pdb5fkj/pdb
• 分子名称: ACETYLCHOLINESTERASE, 1,3-BIS[5(DIETHYL-O-NITROBENZYLAMMONIUM)PENTYL]-6-METHYLURACIL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: hydrolase, acetylcholinesterase, c-547
• 由来する生物種: MUS MUSCULUS (HOUSE MOUSE)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 244389.58

構造登録者

Nachon, F.,Villard-Wandhammer, M.,Petrov, K.,Masson, P. (登録日: 2015-10-16, 公開日: 2016-03-16, 最終更新日: 2024-01-10)

• 主引用文献: Kharlamova, A.D.,Lushchekina, S.V.,Petrov, K.A.,Kots, E.D.,Nachon, F.V.,Villard-Wandhammer, M.,Zueva, I.V.,Krejci, E.,Reznik, V.S.,Zobov, V.V.,Nikolsky, E.E.,Masson, P.; Slow-Binding Inhibition of Acetylcholinesterase by a 6-Methyluracil Alkyl-Ammonium Derivative: Mechanism and Advantages for Myasthenia Gravis Treatment.; Biochem.J., 473:1225-, 2016; PubMed: 26929400; DOI: 10.1042/BCJ20160084

実験手法

X-RAY DIFFRACTION (3.133 Å)