5FIU

Binding and structural studies of a 5,5-difluoromethyl adenosine nucleoside with the fluorinase enzyme

5FIU の概要

• エントリーDOI: 10.2210/pdb5fiu/pdb
• 分子名称: 5'-FLUORO-5'-DEOXY-ADENOSINE SYNTHASE, 5,5-DIFLUOROMETHYL ADENOSINE, L(+)-TARTARIC ACID, ... (4 entities in total)
• 機能のキーワード: transferase, fluorinase, difluoromethyl, isothermal titration calorimetry
• 由来する生物種: STREPTOMYCES CATTLEYA
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 98516.40

構造登録者

Thompson, S.,McMahon, S.A.,Naismith, J.H.,O'Hagan, D. (登録日: 2015-10-02, 公開日: 2015-12-23, 最終更新日: 2024-01-10)

• 主引用文献: Thompson, S.,Mcmahon, S.A.,Naismith, J.H.,O'Hagan, D.; Exploration of a Potential Difluoromethyl-Nucleoside Substrate with the Fluorinase Enzyme.; Bioorg.Chem., 64:37-, 2015; PubMed: 26642178; DOI: 10.1016/J.BIOORG.2015.11.003

実験手法

X-RAY DIFFRACTION (1.84 Å)