5FHR

Crystal structure of Y200L mutant of Rat Catechol-O-Methyltransferase in complex with AdoMet and 3,5-dinitrocatechol

5FHR の概要

• エントリーDOI: 10.2210/pdb5fhr/pdb
• 分子名称: Catechol O-methyltransferase, 3,5-DINITROCATECHOL, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: methyltransferase regioselectivity, transferase
• 由来する生物種: Rattus norvegicus (norway Rat)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49188.64

構造登録者

Levy, C. (登録日: 2015-12-22, 公開日: 2016-02-03, 最終更新日: 2024-01-10)

• 主引用文献: Law, B.J.,Bennett, M.R.,Thompson, M.L.,Levy, C.,Shepherd, S.A.,Leys, D.,Micklefield, J.; Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase.; Angew.Chem.Int.Ed.Engl., 55:2683-2687, 2016; PubMed: 26797714; DOI: 10.1002/anie.201508287

実験手法

X-RAY DIFFRACTION (1.63 Å)