5FHN
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-methylbenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 1.6 A resolution
Summary for 5FHN
Entry DOI | 10.2210/pdb5fhn/pdb |
Related | 2P2A |
Descriptor | Glutamate receptor 2,Glutamate receptor 2, SULFATE ION, GLYCEROL, ... (7 entities in total) |
Functional Keywords | ionotropic glutamate receptor glua2, ligand-binding domain, membrane protein |
Biological source | Rattus norvegicus (Norway Rat) More |
Cellular location | Cell membrane ; Multi-pass membrane protein : P19491 |
Total number of polymer chains | 1 |
Total formula weight | 30024.42 |
Authors | Frydenvang, K.,Kastrup, J.S. (deposition date: 2015-12-22, release date: 2016-03-02, Last modification date: 2024-01-10) |
Primary citation | Wang, S.Y.,Larsen, Y.,Navarrete, C.V.,Jensen, A.A.,Nielsen, B.,Al-Musaed, A.,Frydenvang, K.,Kastrup, J.S.,Pickering, D.S.,Clausen, R.P. Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues. J.Med.Chem., 59:2244-2254, 2016 Cited by PubMed: 26862980DOI: 10.1021/acs.jmedchem.5b01982 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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