5FGB
Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC33.4
5FGB の概要
エントリーDOI | 10.2210/pdb5fgb/pdb |
分子名称 | Anti-HCV E2 Fab HC84-1 light chain, Anti-HCV E2 Fab HC84-1 heavy chain, Genome polyprotein, ... (6 entities in total) |
機能のキーワード | fab fragment, neutralizing antibody, hepatitis c virus e2, immune system |
由来する生物種 | Homo sapiens 詳細 |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P27958 |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 109430.48 |
構造登録者 | |
主引用文献 | Keck, Z.Y.,Girard-Blanc, C.,Wang, W.,Lau, P.,Zuiani, A.,Rey, F.A.,Krey, T.,Diamond, M.S.,Foung, S.K. Antibody Response to Hypervariable Region 1 Interferes with Broadly Neutralizing Antibodies to Hepatitis C Virus. J.Virol., 90:3112-3122, 2016 Cited by PubMed: 26739044DOI: 10.1128/JVI.02458-15 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.65 Å) |
構造検証レポート
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