5FFM

Yellow fever virus helicase

「1YMF」から置き換えられました

5FFM の概要

• エントリーDOI: 10.2210/pdb5ffm/pdb
• 分子名称: Serine protease NS3 (2 entities in total)
• 機能のキーワード: dead helicase rna triphosphatase, hydrolase
• 由来する生物種: Yellow fever virus (strain 17D vaccine) (YFV)
• 細胞内の位置: Capsid protein C: Virion . Peptide pr: Secreted. Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi- pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P03314
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 50010.09

構造登録者

Smith, J.L. (登録日: 2015-12-18, 公開日: 2015-12-30, 最終更新日: 2023-11-15)

• 主引用文献: Wu, J.,Bera, A.K.,Kuhn, R.J.,Smith, J.L.; Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing.; J. Virol., 79:10268-10277, 2005; PubMed: 16051820

実験手法

X-RAY DIFFRACTION (2.6 Å)