5FF1

Two way mode of binding of antithyroid drug methimazole to mammalian heme peroxidases: Structure of the complex of lactoperoxidase with methimazole at 1.97 Angstrom resolution

Summary for 5FF1

• Entry DOI: 10.2210/pdb5ff1/pdb
• Related: 4QJQ
• Descriptor: Lactoperoxidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 1-METHYL-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE, ... (9 entities in total)
• Functional Keywords: inhibitor, peroxidase, oxidoreductase
• Biological source: Capra hircus (Goat)
• Total number of polymer chains: 2
• Total formula weight: 140097.02

Authors

Singh, R.P.,Singh, A.,Sirohi, H.,Singh, A.K.,Kaur, P.,Sharma, S.,Singh, T.P. (deposition date: 2015-12-17, release date: 2016-01-13, Last modification date: 2023-11-08)

• Primary citation: Singh, R.P.,Singh, A.,Sirohi, H.V.,Singh, A.K.,Kaur, P.,Sharma, S.,Singh, T.P.; Dual binding mode of antithyroid drug methimazole to mammalian heme peroxidases - structural determination of the lactoperoxidase-methimazole complex at 1.97 angstrom resolution.; Febs Open Bio, 6:640-650, 2016; PubMed: 27398304; DOI: 10.1002/2211-5463.12051

Experimental method

X-RAY DIFFRACTION (1.97 Å)