5FE7

Crystal structure of human PCAF bromodomain in complex with fragment ZB2216 (fragment 11)

Summary for 5FE7

Entry DOI	10.2210/pdb5fe7/pdb
Descriptor	Histone acetyltransferase KAT2B, 1,2-ETHANEDIOL, 1-(2-hydroxyethyl)-3-methyl-6,7-dihydro-5~{H}-indazol-4-one, ... (5 entities in total)
Functional Keywords	signaling protein, bromodomain, histone acetyltransferase kat2b, histone, acetylation, acetyllysine, epigenetics, structural genomics consortium (sgc)
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q92831
Total number of polymer chains	2
Total formula weight	28803.31
Authors	Chaikuad, A.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2015-12-16, release date: 2016-01-13, Last modification date: 2024-01-10)
Primary citation	Chaikuad, A.,Lang, S.,Brennan, P.E.,Temperini, C.,Fedorov, O.,Hollander, J.,Nachane, R.,Abell, C.,Muller, S.,Siegal, G.,Knapp, S. Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain. J.Med.Chem., 59:1648-1653, 2016 Cited by PubMed: 26731131 DOI: 10.1021/acs.jmedchem.5b01719 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08 Å)

Structure validation