5FDX

Structure of DDR1 receptor tyrosine kinase in complex with D2164 inhibitor at 2.65 Angstroms resolution.

Summary for 5FDX

• Entry DOI: 10.2210/pdb5fdx/pdb
• Descriptor: Epithelial discoidin domain-containing receptor 1, 3-[(4-methylpiperazin-1-yl)methyl]-~{N}-[(4~{R})-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1~{H}-isoquinolin-7-yl]-5-(trifluoromethyl)benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: ddr1 kinase, inhibitors, structural genomics, psi-biology, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted . Isoform 4: Cell membrane; Single-pass type I membrane protein: Q08345
• Total number of polymer chains: 2
• Total formula weight: 78243.47

Authors

Bartual, S.G.,Pinkas, D.M.,Wang, Z.,Ding, K.,Mahajan, P.,Kupinska, K.,Mukhopadhyay, S.,Strain-Damerell, C.,Chalk, R.,Borkowska, O.,Talon, R.,Kopec, J.,Williams, E.,Tallant, C.,Chaikuad, A.,Sorell, F.,Newman, J.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2015-12-16, release date: 2016-10-26, Last modification date: 2024-01-10)

• Primary citation: Bartual, S.G.,Ding, K.,Wang, Z.,Bullock, N.A.; Structure of DDR1 receptor tyrosine kinase in complex with D2164 inhibitor at 2.65 Angstroms resolution.; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.65 Å)