5FDX

Structure of DDR1 receptor tyrosine kinase in complex with D2164 inhibitor at 2.65 Angstroms resolution.

5FDX の概要

• エントリーDOI: 10.2210/pdb5fdx/pdb
• 分子名称: Epithelial discoidin domain-containing receptor 1, 3-[(4-methylpiperazin-1-yl)methyl]-~{N}-[(4~{R})-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1~{H}-isoquinolin-7-yl]-5-(trifluoromethyl)benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: ddr1 kinase, inhibitors, structural genomics, psi-biology, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted . Isoform 4: Cell membrane; Single-pass type I membrane protein: Q08345
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 78243.47

構造登録者

Bartual, S.G.,Pinkas, D.M.,Wang, Z.,Ding, K.,Mahajan, P.,Kupinska, K.,Mukhopadhyay, S.,Strain-Damerell, C.,Chalk, R.,Borkowska, O.,Talon, R.,Kopec, J.,Williams, E.,Tallant, C.,Chaikuad, A.,Sorell, F.,Newman, J.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (登録日: 2015-12-16, 公開日: 2016-10-26, 最終更新日: 2024-01-10)

• 主引用文献: Bartual, S.G.,Ding, K.,Wang, Z.,Bullock, N.A.; Structure of DDR1 receptor tyrosine kinase in complex with D2164 inhibitor at 2.65 Angstroms resolution.; To Be Published,

実験手法

X-RAY DIFFRACTION (2.65 Å)