5FDQ

Murine COX-2 S530T mutant

5FDQ の概要

• エントリーDOI: 10.2210/pdb5fdq/pdb
• 関連するPDBエントリー: 5F19 5F1A
• 分子名称: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: cyclooxygenase, cyxlooxygenase-2, monotopic, cox-2, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 139969.79

構造登録者

Lucido, M.J.,Orlando, B.J.,Malkowski, M.G. (登録日: 2015-12-16, 公開日: 2016-03-16, 最終更新日: 2023-09-27)

• 主引用文献: Lucido, M.J.,Orlando, B.J.,Vecchio, A.J.,Malkowski, M.G.; Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.; Biochemistry, 55:1226-1238, 2016; PubMed: 26859324; DOI: 10.1021/acs.biochem.5b01378

実験手法

X-RAY DIFFRACTION (1.9 Å)