5FDL

Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with IDX899

5FDL の概要

• エントリーDOI: 10.2210/pdb5fdl/pdb
• 分子名称: P51 Reverse transcriptase, P66 Reverse transcriptase, methyl (R)-(2-carbamoyl-5-chloro-1H-indol-3-yl)[3-(2-cyanoethyl)-5-methylphenyl]phosphinate (3 entities in total)
• 機能のキーワード: hiv-1 reverse transcriptase, phosphoindole, nnrti, mutation, hydrolase
• 由来する生物種: Human immunodeficiency virus 1 (HIV-1); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115798.16

構造登録者

Dousson, C.B.,Alexandre, F.-R.,Convard, T.,Fisher, M.,Lamers, M.B.A.C.,Leonard, P.M. (登録日: 2015-12-16, 公開日: 2016-02-17, 最終更新日: 2024-01-10)

• 主引用文献: Dousson, C.,Alexandre, F.R.,Amador, A.,Bonaric, S.,Bot, S.,Caillet, C.,Convard, T.,da Costa, D.,Lioure, M.P.,Roland, A.,Rosinovsky, E.,Maldonado, S.,Parsy, C.,Trochet, C.,Storer, R.,Stewart, A.,Wang, J.,Mayes, B.A.,Musiu, C.,Poddesu, B.,Vargiu, L.,Liuzzi, M.,Moussa, A.,Jakubik, J.,Hubbard, L.,Seifer, M.,Standring, D.; Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor.; J.Med.Chem., 59:1891-1898, 2016; PubMed: 26804933; DOI: 10.1021/acs.jmedchem.5b01430

実験手法

X-RAY DIFFRACTION (3.1 Å)