5FCK

COMPLEMENT FACTOR D IN COMPLEX WITH COMPOUND 5

Summary for 5FCK

DescriptorComplement factor D, 1-[2-[(1~{R},3~{S},5~{R})-3-[[(1~{R})-1-(3-chloranyl-2-fluoranyl-phenyl)ethyl]carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxidanylidene-ethyl]pyrazolo[3,4-c]pyridine-3-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywordshydrolase
Biological sourceHomo sapiens (Human)
Cellular locationSecreted P00746
Total number of polymer chains1
Total molecular weight25320.09
Authors
Mac Sweeney, A. (deposition date: 2015-12-15, release date: 2016-10-26, Last modification date: 2016-11-23)
Primary citation
Maibaum, J.,Liao, S.M.,Vulpetti, A.,Ostermann, N.,Randl, S.,Rudisser, S.,Lorthiois, E.,Erbel, P.,Kinzel, B.,Kolb, F.A.,Barbieri, S.,Wagner, J.,Durand, C.,Fettis, K.,Dussauge, S.,Hughes, N.,Delgado, O.,Hommel, U.,Gould, T.,Mac Sweeney, A.,Gerhartz, B.,Cumin, F.,Flohr, S.,Schubart, A.,Jaffee, B.,Harrison, R.,Risitano, A.M.,Eder, J.,Anderson, K.
Small-molecule factor D inhibitors targeting the alternative complement pathway.
Nat.Chem.Biol., 12:1105-1110, 2016
PubMed: 27775713 (PDB entries with the same primary citation)
DOI: 10.1038/nchembio.2208
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.86 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.243803.9%2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution